corosorbide,Isosorbide dinitrate,cas:87-33-2 CAS NO.87-33-2
- FOB Price: USD: 80.00-120.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
%(1-200)Kilogram%(500-5000)Kilogram
- Product Details
Keywords
- 87-33-2
- Isosorbide dinitrate
- cedocard
Quick Details
- ProName: corosorbide,Isosorbide dinitrate,cas:8...
- CasNo: 87-33-2
- Molecular Formula: C6H8N2O8
- Appearance: white powder
- Application: Use coronary artery dilator for the tr...
- DeliveryTime: Shipped in 15 days after payment
- PackAge: according to customers' requirements
- Port: China main port
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: %
- Storage: -20?C Freezer
- Transportation: Air, sea, land transport
- LimitNum: 1 Kilogram
Superiority
Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.
Details
Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.