High quality Phentolamine mesilate 65-28-1 CAS NO.65-28-1
- FOB Price: USD: 2.00-3.00 /Gram Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
99%(1-9)Gram99%(11-20)Gram
- Product Details
Keywords
- 65-28-1
- Phentolamine mesilate
- Cardiovascular diseases, diabetes, kidney disease, and toxic enteroplegia
Quick Details
- ProName: High quality Phentolamine mesilate 65-...
- CasNo: 65-28-1
- Molecular Formula: C18H23N3O4S
- Appearance: White Crystalline Powder
- Application: Cardiovascular diseases, diabetes, kid...
- DeliveryTime: Within 3 workdays after payment
- PackAge: 1kg/BAG,25kg/DRUM,according to custom...
- Port: China main port
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Refrigerator
- Transportation: Air, sea, land transport
- LimitNum: 1 Gram
- Related Substances: 0
- Residue on Ignition: <0.5
- Heavy Metal: <0.003%
- Valid Period: 2 years
Superiority
Details
It also has usefulness in the treatment of cocaine-induced cardiovascular complications, where one would generally avoid β-blockers (e.g. metoprolol), as they can cause unopposed α-adrenergic mediated coronary vasoconstriction, worsening myocardial ischemia and hypertension.
It is important to note that phentolamine is not a first-line agent for this indication. Phentolamine should only be given to patients who do not fully respond to benzodiazepines, nitroglycerin, and calcium channel blockers.
When given by injection it causes blood vessels to dilate, thereby increasing blood flow. When injected into the penis(intracavernosal), it increases blood flow to the penis, which results in an erection.
It may be stored in crash carts to counteract severe peripheral vasoconstriction secondary to extravasation of peripherally placed vasopressor infusions, typically of norepinephrine. Epinephrine infusions are less vasoconstrictive than norepinephrine as they primarily stimulate β receptor more than α receptors, but the effect remains dose-dependent.
Phentolamine also has diagnostic and therapeutic roles in complex regional pain syndrome (reflex sympathetic dystrophy).
Phentolamine is marketed in the dental field as a local anesthetic reversal agent. Branded as OraVerse, it is a phentolamine mesylate injection designed to reverse the local vasoconstrictor properties used in many local anesthetics to prolong anesthesia.