Anti-bacterial drugs Nitazoxanide with CAS:55981-09-4 CAS NO.55981-09-4

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99%(1-9)Kilogram157.8/Kilogram1USD99%(10-20)Kilogram132.6/Kilogram10USD

Product Details

Keywords

55981-09-4
Nitazoxanide
EINECS: 259-931-8

Quick Details

ProName: Anti-bacterial drugs Nitazoxanide with...
CasNo: 55981-09-4
Molecular Formula: C12H9N3O5S
Appearance: Crystalline Solid
Application: An anthelmintic (cestodes), antiproto...
DeliveryTime: Shipped in 15 days after payment
PackAge: according to customers' requirements
Port: China main port
ProductionCapacity: 10000 Metric Ton/Month
Purity: 99%min
Storage: -20°C Freezer
Transportation: Air, sea, land transport
LimitNum: 1 Kilogram
Residue on Ignition: 0.14%
Heavy Metal: ≤10ppm
Valid Period: 2 years

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Details

Introduction:

Chemical Name: 2 - acetoxy-N-(5 - nitro -2-- thiazolyl) benzamide

CAS No: 55981-09-4

Molecular formula: C12H9N3O5S

MW: 307.28

Quality:

Appearance: Light yellow to white crystalline powder

Content (HPLC): greater than 99.0%

Melting point: 196-202 ℃ Loss on drying: less than 0.5% Max

Use: anti-bacterial drugs

This product is a nitrate thiophene amide derivatives of salicylic acid, although the actual mechanism has not yet clear, but is thought to inhibit the pyruvate, ferredoxin oxidoreductase enzyme-dependent electron transfer reaction on and after by the anaerobic energy metabolism is essential. In addition to the intestinal Cryptosporidium parvum and Giardia lamblia in addition, the product of many intestinal parasites such as Cryptosporidium, such as Bayesian, amoeba, human roundworm, hookworm, whipworm hair first, beef tapeworm, short film Shell has tapeworm and Fasciola activity.

In addition, the product of certain anaerobic and aerobic micro, such as Helicobacter pylori also has activity. According to June 13, 2006 the British medical journal "Lancet" published an article shows nitazoxanide result due to rotavirus diarrhea in children also has a good effect.

Nitazoxanide has antiprotozoal, anti-intestinal parasites, antibacterial, antiviral efficacy, etc., and the spectrum anti-parasitic and antibacterial spectrum than albendazole, mebendazole and metronidazole wide range of application fields than other Drugs widely used.

Function:

(A) of the antiprotozoal

Cryptosporidiosis Cryptosporidiosis is a zoonotic parasitic disease worldwide, the pathogen is a compound belonging to the top of the door of the parasitic protozoa - Cryptosporidium. The disease can infect humans, pigs, cattle, sheep, mice and other animals, poultry, to severe diarrhea, dehydration, weight loss, the main symptoms. And nitazoxanide for the treatment of cryptosporidiosis cure experiments show that the curative effect.

It is reported that 100 cases were suffering from diarrhea caused by Cryptosporidium parvum by the Egyptian patients (children account for half) to accept 3-day treatment of this product, children of 100 mg or 200 mg bid (bid on behalf of 2 times a day), adult 500 mg bid , (next page) (continued on next page) to placebo as a control. Treatment group and control group cure rates were 80% (39/49) and 41% (20/49), compared the two groups statistically significant difference.

In addition, many tests prove that nitazoxanide against Entamoeba protozoosis, Bayesian and other spores and other primary echinococcosis echinococcosis have some effect.

(B) for other intestinal parasites

In recent years, experiments have shown that nitazoxanide in the treatment of Ascaris, Trichuris, Hymenolepis less than the cure when the effect of albendazole and praziquantel. Tapeworm in the morphology and ultrastructure of alternating observations, nitazoxanide makes undifferentiated cells vacuolization, accumulation of small droplets, micro-hair shedding. Nitazoxanide insecticidal mechanism of this amino acid is different from traditional acrylic imidazolium salts (such as mebendazole) anti-worm drugs, insect suppression does not change the killing of the situation. In addition, nitazoxanide Demodex live on the intestinal nematode, Trichuris whip and Hymenolepis nana, sheep Sihamonis tapeworm, beef tapeworm, and a short film sash shell and some intestinal tapeworms and other intestinal nematodes have effect.

Nitazoxanide intractable Clostridium, Helicobacter pylori has strong inhibition and killing effect. Use of refractory Clostridium infection in a rat model of determination of nitazoxanide minimum inhibitory concentration (MICs) and minimum bactericidal concentrations (MBCs), toxicity, drug resistance, etc. The results show that: nitazoxanide the MICs and MBCs with vancomycin or metronidazole up to azole similar, were 0.25 g / ml and 0.50 g / ml. But nitazoxanide treatment of infected rats survived the autopsy, no obvious toxicity or Clostridium caused by intestinal disease, which is better than that of vancomycin and metronidazole azole.

Nitazoxanide when combined with omeprazole, eradication of H. pylori has a high rate of drug resistance and will not appear. But studies have shown that nitazoxanide as a single therapeutic agent can not eradicate H. pylori.

(D) Anti-Virus

U.S. Romark Institute for Medical Research study shows that: a severe rotavirus diarrhea in children taking nitazoxanide 3 days, make their recovery time was significantly shortened.

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Production Inspection Process:

Our Group service includes regular and thorough inspections throughout the manufacturing process, eliminating the need to employ additional quality control inspectors.

- Raw material before any production begins

- Pre-production samples to ensure specifications are being met

- In-process to confirm that standards are maintained

- Pre-shipping to ensure that the product arrives to the customer exactly as expected and is packaged

correctly to prevent any damage in transit.

We can help operating split shipments, meeting the factory minimum quantity but ship them in 2 or 3 shipments with required gaps among. This allows you to move stock through your business without taking up space and capital.

We will arrange the subsequent shipments from our factory to your warehouse.

We can consolidate your small orders from multiple factories, delivering all at the same time to you or your customers,using the most cost-effective route available. At the time of order placement, we will offer details to you about the volume of each component part and what size container will be used.

We can offer the complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.

Delivery can be offered.

- Utilizing your own freight-forwarder

- FOB to a port in China

- CIF to a port near you

Whether you have your own freight-forwarder or you would like to organize shipment; whether you require delivery FOB in China or CIF to a port near you, we are glad to quote and supply whichever way you choose. Please feel free to discuss all options with us.