AN anti-tumor and anti-drug resistance effects Tamoxifen citrateCAS:54965-24-1 CAS NO.54965-24-1

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99%(1-9)Kilogram363/Kilogram1USD99%(10-20)Kilogram352/Kilogram10USD

Product Details

Keywords

Tamoxifen citrate
54965-24-1
Aluminium chloride-->Bromoethane-->Phenylacetic acid-->4-Bromophenol

Quick Details

ProName: AN anti-tumor and anti-drug resistance...
CasNo: 54965-24-1
Molecular Formula: C32H37NO8
Appearance: White to off-white powder
Application: anti-estrogen, protein kinase C inhibi...
DeliveryTime: Shipped in 15 days after payment
PackAge: according to customers' requirements
Port: China main port
ProductionCapacity: 10000 Metric Ton/Month
Purity: 99%
Storage: 2-8°C
Transportation: Air, sea, land transport
LimitNum: 1 Kilogram
Residue on Ignition: 0.50% max
Heavy Metal: 0.001%max
Valid Period: 2 years

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Details

Introduction:

Tamoxifen Citrate is a potent and selective inhibitor of PKC (protein kinase C). It is known that Tamoxifen Citrate functions in PKC εtranslocation. Studies suggest that Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Once bound to the estrogen receptor Tamoxifen Citrate will not allow any other ligand to bind to the receptor. In contrast, Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Studies indicate Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor.

Function:

Tamoxifen is an anticancer drug, is given to treat breast cancer.

Tamoxifen citrate is an anticancer drug, is given to treat breast cancer. It also has proved effective when cancer has spread to other parts of the body. Tamoxifen citrate is most effective in stopping the kind of breast cancer that thrives on estrogen.

Tamoxifen citrateis also prescribed to reduce the risk of invasive breast cancer following surgery and radiation therapy for ductal carcinoma in situ. The drug can also be used to reduce the odds of breast cancer in women at high risk of developing the disease. It does not completely eliminate your chances, but in a five-year study of over 1,500 high-risk women, it slashed the number of cases by 44 percent.

Most important fact about Tamoxifen citrate

Although Tamoxifen citrate reduces the risk of breast cancer, it increases the possibility of developing endometrial (uterine) cancer. Women taking Tamoxifen citrate should have routine gynecological examinations and report any abnormal vaginal bleeding, changes in menstrual periods, change in vaginal discharge, or pelvic pain or pressure to the doctor immediately. Even after Tamoxifen citratetherapy has stopped, any abnormal vaginal bleeding should be reported at once.

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