Best quality Pharmaceutical Grade Indomethacin/indometacin CAS 53-86-1 CAS NO.53-86-1

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Min.Order: 1 Kilogram
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Available Specifications:
99%(1-50)Kilogram30/Kilogram1USD99%(51-100)Kilogram28/Kilogram51USD

Product Details

Keywords

53-86-1
Indometacin
Anti-inflammatory analgesics

Quick Details

ProName: Best quality Pharmaceutical Grade Indo...
CasNo: 53-86-1
Molecular Formula: C19H16ClNO4
Appearance: White or yellowish crystalline powder
Application: Indomethacin, also known as indomethac...
DeliveryTime: Within 3 workdays after payment
PackAge: 1kg/BAG,25kg/DRUM,according to custom...
Port: China main port
ProductionCapacity: 10000 Metric Ton/Month
Purity: 99%
Storage: Store at RT
Transportation: Air, sea, land transport
LimitNum: 1 Kilogram
Related Substances: 0
Residue on Ignition: <0.5
Heavy Metal: <0.003%
Valid Period: 2 years

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Details

[English Name] Indometacin

[Test Method]HPLC

[Purity]≥99%

[CAS No.]53-86-1

[Mol. Formula]C19H16ClNO4

[Mol. Weight]236.27

[Purity]> 99% by HPLC

Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM)over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ(peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis. Other studies show indomethacin to stabilize cholesterol-dependent nanoclusters and enhance phase separation in biological membranes, which could consequentially effect plasma membrane assembled cell signaling cascades. Indomethacin is an activator of PPAR α.

Function:

Indometacin has also been used clinically to delay premature labor, reduce amniotic fluid in polyhydramnios, and to close patent ductus arteriosus.

Indometacin is a potent drug with many serious side effects and should not be considered an analgesic for minor aches and pains or fever. The medication is better described as an anti-inflammatory, rather than an analgesic. Indometacin can also affect warfarin and subsequently raise INR.This product has obvious effect on anti-inflammation and antipyretic, can be easily absorbed and excreted. It can be fully absorbed after taken orally in the gastrointestinal tract, and in 1-4 hours the plasma concentration will reach a peak; it will be excreted by liver metabolism, with the urine. Analgesic effects on inflammatory pain there, and its mechanism of

inhibiting prostaglandin synthesis. Salicylic acid is mainly used on the efficacy of drugs difficult to tolerate, or not significant rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and so on. Can also be used for acute gout and cancer, fever, or other difficult to control fever.

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Production Inspection Process:

Our Group service includes regular and thorough inspections throughout the manufacturing process, eliminating the need to employ additional quality control inspectors.

- Raw material before any production begins

- Pre-production samples to ensure specifications are being met

- In-process to confirm that standards are maintained

- Pre-shipping to ensure that the product arrives to the customer exactly as expected and is packaged

correctly to prevent any damage in transit.

We can help operating split shipments, meeting the factory minimum quantity but ship them in 2 or 3 shipments with required gaps among. This allows you to move stock through your business without taking up space and capital.

We will arrange the subsequent shipments from our factory to your warehouse.

We can consolidate your small orders from multiple factories, delivering all at the same time to you or your customers,using the most cost-effective route available. At the time of order placement, we will offer details to you about the volume of each component part and what size container will be used.

We can offer the complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.

Delivery can be offered.

- Utilizing your own freight-forwarder

- FOB to a port in China

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Whether you have your own freight-forwarder or you would like to organize shipment; whether you require delivery FOB in China or CIF to a port near you, we are glad to quote and supply whichever way you choose. Please feel free to discuss all options with us.