Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis.
Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges (Strepsils Intensive).
A single enantiomer of flurbiprofen, tarenflurbil [(R)-flurbiprofen)], is currently in clinical trials for the treatment of metastatic prostate cancer.
Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis.
Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges (Strepsils Intensive).
A single enantiomer of flurbiprofen, tarenflurbil [(R)-flurbiprofen)], is currently in clinical trials for the treatment of metastatic prostate cancer
[Indications of efficacy] mainly used for rheumatoid arthritis. Suitable for relieving postoperative pain and various
forms of cancer.
[Chemical composition]the fluorine flurbiprofen.
[Pharmacological] this product is a non-steroidal anti-inflammatory drugs, formed in the body after intravenous
flurbiprofen works. Its mechanism is similar to other non-steroidal anti-inflammatory drugs, by blocking prostaglandin biosynthesis and function. This products of analgesic role, by acetic acid induced of twisted test, and nandall-selatto test, and arthritis pain, animal (small rat, and big rat) model compared has its and o Republika horse forest lysine, and ketone ibuprofen and analgesic new of effectiveness, results this products effectiveness and muscle note analgesic new equal or slightly strong, than muscle note ketone ibuprofen or static note o Republika horse forest lysine strong, role continued time also long. The safety of this product on the formation of gastric ulcer index with these drugs is equal to or a little larger.
[Drug interactions]it reduced the frusemide the diuretic effect, but enhance the anticoagulant of coumarin (warfarin).Similar compounds (fenbufen) quinolones and sharing, there are rare reports of convulsions.
[Adverse reaction] individual cases of indigestion, skin rashes, gastrointestinal ulcers, gastrointestinal bleeding, transaminase. renal papillary necrosis. Clinical trial adverse reaction cases in 1089, 32 cases of adverse reactions occurred 38 times (2.9%). There are angry, vomiting, diarrhea and other digestive symptoms and feeling hot, sleepy, chills and other symptoms of the nervous system. Abnormal clinical examination, primarily for GPT (1.1%), GOT (1%) and the ALP slightly increased. Sometimes blood pressure and heart rate. In addition rare headaches, tiredness, itching and rashes, and injection site pain and bleeding under the skin.
[Contraindications] special attention to the elderly and the occurrence of side effects in children, given to them be careful, limited to the necessary minimum. The patient disabled: 1. cyclophosphamide in patients with peptic ulcer; 2.serious blood anomalies in patients with c in patients with severe hepatic and renal dysfunction about patients with severe cardiac insufficiency;3.in patients with allergic to this product ingredients; 4. aspirin asthma (asthma induced by non-steroidal anti-inflammatory drugs) history. Used with caution in patients with the following follows:1. persons with a history of peptic ulcer hemogram abnormalities c liver and kidney dysfunction, about patients with heart dysfunction; 2.with a history of allergies; 3. in patients with bronchial asthma; 4. sadly, older people.