Introduction:
Name: Allopurinol
Synonyms: 4-Hydroxypyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidin-4-ol; HPP
Molecular Formula: C5H4N4O
Molecular Weight: 136.11
CAS NO: 315-30-0
EINECS: 206-250-9
Quality standard: USP33, EP6.8 Pass GMP
Melting point: 350 ºC
Water solubility: 0.35 g/L (25 ºC)
Physical and Chemical Properties: White or white powder, insoluble in water.
function:
Allopurinol CAS 315-30-0 can cause severe pancytopenia if given with full-dose mercaptopurine or its pro-drug azathioprine, due to the inhibition of xanthine oxidase that metabolizes mercaptopurine. For this reason, allopurinol CAS 315-30-0 has been strongly contraindicated during thiopurine therapy in the past. However, in recent years the use of allopurinol cas 315-30-0 in combination with azathioprine or mercaptopurine has been revived. First, allopurinol cas 315-30-0 was shown that an azathioprine/allopurinol combination significantly improved renal transplant graft survival. More recently, allopurinol cas 315-30-0 was discovered that this co-therapy greatly improves the outcome for patients that do not respond to thiopurine monotherapy when treating inflammatory bowel disease (IBD), specifically Crohn's disease.
4. Reperfusion injury
Other established indications for allopurinol therapy include ischemic reperfusion injury, kidney stones with a uric acid component (uric acid nephrolithiasis), and protozoal infections (Leishmaniasis).
5. Renal disease, Heart failure and Angina
Allopurinol can be used in patients with poor kidney function, but it may also help them. A study of allopurinol use in patients with chronic kidney disease suggested that "Allopurinol decreases C-reactive protein and slows down the progression of renal disease in patients with chronic kidney disease. In addition, allopurinol reduces cardiovascular and hospitalization risk in these subjects."
6. Epilepsy
Allopurinol CAS 315-30-0 is used as an add-on drug for refractory epilepsy, because it is an adenosine agonist, which inhibits glutamine release from excitatory neurons, but does not change the plasma concentration of other epilepsy drugs.
7. Blood pressure
Allopurinol CAS 315-30-0 can decrease blood pressure reducing hypertension.
Specification:
All Key Manufacturers and Suppliers of Baoji Guokang have routine inspections to ensure they are in compliance with the standards set in place during the original Supplier Assessment Inspection.
Production Inspection Process:
Our Group service includes regular and thorough inspections throughout the manufacturing process, eliminating the need to employ additional quality control inspectors.
- Raw material before any production begins
- Pre-production samples to ensure specifications are being met
- In-process to confirm that standards are maintained
- Pre-shipping to ensure that the product arrives to the customer exactly as expected and is packaged
correctly to prevent any damage in transit.
We can help operating split shipments, meeting the factory minimum quantity but ship them in 2 or 3 shipments with required gaps among. This allows you to move stock through your business without taking up space and capital.
We will arrange the subsequent shipments from our factory to your warehouse.
We can consolidate your small orders from multiple factories, delivering all at the same time to you or your customers,using the most cost-effective route available. At the time of order placement, we will offer details to you about the volume of each component part and what size container will be used.
We can offer the complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.
Delivery can be offered.
- Utilizing your own freight-forwarder
- FOB to a port in China
- CIF to a port near you
Whether you have your own freight-forwarder or you would like to organize shipment; whether you require delivery FOB in China or CIF to a port near you, we are glad to quote and supply whichever way you choose. Please feel free to discuss all options with us.
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