Tenofovir disoproxil /CAS:201341-05-1 CAS NO.201341-05-1

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Product Details

Keywords

Tenofovir disoproxil
201341-05-1
EINECS: 111-111-1

Quick Details

ProName: Tenofovir disoproxil /CAS:201341-05-1
CasNo: 201341-05-1
Molecular Formula: C19H30N5O10P
Appearance: White powder
Application: Tenofovir disoproxil belongs to a cla...
DeliveryTime: Shipped in 15 days after payment
PackAge: according to customers' requirements
Port: China main port
ProductionCapacity: 10000 Metric Ton/Month
Purity: 98%min
Storage: -20°C
Transportation: Air, sea, land transport
LimitNum: 1 Kilogram
Residue on Ignition: 0.1% max
Heavy Metal: 10ppm max
Valid Period: 2 years

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Details

Introduction:

CAS: 201341-05-1

Molecular formula: C19H30N5O10P

Molecular weight: 519.445

Melting point: 286-289 ° C

This product is white crystalline powder; at room temperature is relatively stable, hygroscopicity, 25 ℃ when the water solubility of 13.4mg / ml, optical rotation of -18 ° -22 °. It is a novel nucleotide reverse transcriptase inhibitor, can be effective against a variety of viruses, for the treatment of viral infectious diseases, retroviruses and hepatitis B virus has a strong inhibitory effect.

Tenofovir is an acyclic nucleoside antiviral drug that has the effect of inhibiting HBV polyglucoside and HIV reverse transcriptase. The active ingredient of tenofovir is the direct competitive Binds to a natural deoxyribose substrate and inhibits viral polymerase, and terminates the chain by inserting DNA. Is the first nucleotide analogue to be approved by the US Food and Drug Administration (FDA) for HIV-1 infection.

Tylenolide is a drug in AIDS cocktail therapy, and studies have shown that it can effectively improve the monkey's ability to prevent immunodeficiency virus (similar to human HIV).

Tylenolide is hardly absorbed by the gastrointestinal tract and is therefore esterified and salt to become tannofloxacin fumarate. Tylenolide is water-soluble and can be rapidly absorbed and degraded into the active substance, tenorofovir, and then tenofovir is transformed into the active metabolite tannofloxacin. The peak value of tenonovudine blood was measured within 1 to 2 hours after dosing. Tylenolide and food service can increase bioavailability by about 40%. Tennofine bisphosphonates have an intracellular half-life of about 10 h and can be administered once a day. Since the drug is not metabolized by the CYP450 enzyme, the possibility of interaction with other drugs caused by the enzyme is small. The drug mainly by glomerular filtration and active tubule transport system excretion, about 70% to 80% of the prototype by the urine excreted. For the treatment of HIV, HBV infection. This product and other reverse transcriptase inhibitors for HIV-1 infection, hepatitis B treatment.

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