Hycamtin,Topotecan hydrochloride,cas:119413-54-6 CAS NO.119413-54-6
- FOB Price: USD: 6,880.00-6,894.00 /Kilogram Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
%(1-50)Kilogram%(100-200)Kilogram
- Product Details
Keywords
- 119413-54-6
- Topotecan hydrochloride
- Hycamtin
Quick Details
- ProName: Hycamtin,Topotecan hydrochloride,cas:1...
- CasNo: 119413-54-6
- Molecular Formula: C23H24ClN3O5
- Appearance: white powder
- Application: Topitaikang Hydrochloride is a third g...
- DeliveryTime: Shipped in 15 days after payment
- PackAge: according to customers' requirements
- Port: China main port
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Refrigerator
- Transportation: Air, sea, land transport
- LimitNum: 1 Gram
Superiority
- Topotecan Hydrochloride (Topotecan HCl) is a semi-synthetic derivative of camptothecin. Camptothecin is a natural product extracted from the bark of the tree Camptotheca acuminata. Topoisomerase-I is a nuclear enzyme that relieves torsional strain in DNA by opening single strand breaks. Once topoisomerase-I creates a single strand break, the DNA can rotate in front of the advancing replication fork. Topotecan intercalates between DNA bases. This intercalation disrupts the DNA deplication machinery when it reaches a site where topotecan is intercalated.
- Topotecan is an antineoplastic agent used to treat small cell lung cancer, and certain cancers of the ovary.
- Topotecan is also used to treat relapse of small cell lung cancer that initially responded to other drugs. Increases in survival times have been observed in patients treated with topotecan compared to control populations treated with paclitaxel.
Details
1.English name:Topotecan
2.Molecular Formula:C23H23N3O5
3.Molecular Weight:421.4458
4.CAS Registry Number:123948-87-8
5.Quality:98%
6.Density:1.49g/cm3
7.Boiling point:782.9°C at 760 mmHg
8.Refractive index:1.733 Flash point:427.3°C
9.Vapour Pressur:8.13E-26mmHg at 25°C
1.Topological treatment of first-line chemotherapeutic sensitive recurrent small cell lung cancer is similar or better, and good tolerance, easy to take, low hematological toxicity;
2. Topological tiikang oral formulation as the second-line treatment of ovarian cancer has a good effect, convenient to take, low hematologic toxicity and good tolerance;
3.Oral topotikang capsule combined with cisplatin is a safe and effective drug for the treatment of widespread small cell lung cancer.