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pharmaceutical raw material Ibrutinib /CAS：936563-96-1 CAS NO.936563-96-1
- FOB Price: USD: 2,986.00-3,030.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
99%(100-200)Gram99%(200-300)Gram
- Product Details
Keywords
- 936563-96-1
- Ibrutinib
- Anticancer
Quick Details
- ProName: pharmaceutical raw material Ibrutinib...
- CasNo: 936563-96-1
- Molecular Formula: C25H24N6O2
- Appearance: White powder
- Application: Ibrutinib is a kind of Bruton tyrosine...
- DeliveryTime: Shipped in 15 days after payment
- PackAge: according to customers' requirements
- Port: China main port
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: 2-8°C
- Transportation: Air, sea, land transport
- LimitNum: 100 Gram
- Related Substances: 0.02%
- Residue on Ignition: 0.10% max
- Heavy Metal: 8ppm
- Valid Period: 2 years
Superiority
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present, our customers have spread all over the world, we have rich Transportation experience, we aim to serve customers, to help customers, solve problems for customers. Look forward to working with you!
Details
Introduction:
Ibrutinib is a small molecule BTK inhibitor that binds covalently to cysteine residues in the active site of BTK, thereby inhibiting its activity. BTK full name Bruton'styrosinekinase, transmits signals in the BCR signaling pathway and cytokine receptor signaling pathway, mediates B cell migration, chemotaxis, and adhesion. Preclinical studies have demonstrated that ibrutinib can inhibit the proliferation and survival of malignant B cells.Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.
Function：
Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm).
Specification：
All Key Manufacturers and Suppliers of Baoji Guokang have routine inspections to ensure they are in compliance with the standards set in place during the original Supplier Assessment Inspection.
Production Inspection Process:
Our Group service includes regular and thorough inspections throughout the manufacturing process, eliminating the need to employ additional quality control inspectors.
- Raw material before any production begins
- Pre-production samples to ensure specifications are being met
- In-process to confirm that standards are maintained
- Pre-shipping to ensure that the product arrives to the customer exactly as expected and is packaged
correctly to prevent any damage in transit.
We can help operating split shipments, meeting the factory minimum quantity but ship them in 2 or 3 shipments with required gaps among. This allows you to move stock through your business without taking up space and capital.
We will arrange the subsequent shipments from our factory to your warehouse.
We can consolidate your small orders from multiple factories, delivering all at the same time to you or your customers,using the most cost-effective route available. At the time of order placement, we will offer details to you about the volume of each component part and what size container will be used.
We can offer the complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.
Delivery can be offered.
- Utilizing your own freight-forwarder
- FOB to a port in China
- CIF to a port near you
Whether you have your own freight-forwarder or you would like to organize shipment; whether you require delivery FOB in China or CIF to a port near you, we are glad to quote and supply whichever way you choose. Please feel free to discuss all options with us.
1.Client is first.We are trying to bring maximum profit to our clients and we only share small.
2.Credibility is the most important.
3.Quality control is our life.
4.Great sense of responsibility.
We will be responsible for not only our products, our clients, our suppliers, also the society.
