TALNETANT 174636-32-9 CAS NO.174636-32-9

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SB 223412 Basic information

Product Name:	SB 223412
Synonyms:	SB 223412;3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;(-)-(S)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxaMide;TALNETANT//SB223412//3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide;SB-223412; SB223412; SB 223412;Talnetant (SB 223412);CS-1123;Talnetant/(S)-3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
CAS:	174636-32-9
MF:	C25H22N2O2
MW:	382.45
EINECS:
Product Categories:
Mol File:	174636-32-9.mol

SB 223412 Chemical Properties

Melting point	125.1-126.2℃
Boiling point	580.4±50.0 °C(Predicted)
density	1.212±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO: soluble25mg/mL, clear
pka	6.70±0.50(Predicted)
form	powder
color	white to beige
optical activity	[α]/D -25 to -31°, c = 0.5 in methanol

Safety Information

Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII

MSDS Information

SB 223412 Usage And Synthesis

Description

Talnetant is an antagonist of the neurokinin-3 (NK3) receptor (Ki = 1 nM). It is selective for NK3 over NK1 and NK2 receptors (Kis = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B (Item No. 24542) in HEK293 cells expressing human NK3 receptors (IC50 = 16.6 nM). It inhibits contractions induced by the NK3 receptor agonist senktide (Item No. 16721) in isolated rabbit iris sphincter muscle (pD2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.

Function&Application

1. Important organic raw materials and dye intermediates for the manufacture of toluic acid, butyric acid, β-naphthol-3-carboxylic acid, and used in the manufacture of anti-aging agents, anti-aging agents DNP and other antioxidants, organic pigments and fungicides. Wait.

2. As a reagent for the determination of sulfonamides and aromatic amines by thin layer chromatography. Also used in organic synthesis.

3. Used in acid tin plating to increase cathode polarization, refine crystallization, and reduce porosity. Since the product is water-repellent, when the content is too high, gelatin will be precipitated and the coating will be streaked.

4. Mainly used for the production of Acid Orange Z, Acid Orange II, Acid Black ATT, Acid Medium Black T, Acid Medium Black A, Acid Medium Black R, Acid Complex Pink B, Acid Complex Red Brown BRRW, Acid Complex Black WAN, phenolic phenol AS, phenolic phenol AS-D, phenolic phenol AS-OL, phenolic phenolic AS-SW, reactive brilliant orange X-GN, reactive brilliant orange K-GN, reactive red K-1613, neutral violet BL, medium Sex black BGL, direct copper salt blue 2R, direct fast blue B2PL, direct blue RG, direct blue RW and other dyes

 

   All Key Manufacturers and Suppliers of Baoji Guokang have routine inspections to ensure they are in compliance with the standards set in place during the original Supplier Assessment Inspection.

 

Production Inspection Process:

Our Group service includes regular and thorough inspections throughout the manufacturing process, eliminating the need to employ additional quality control inspectors.

- Raw material before any production begins

- Pre-production samples to ensure specifications are being met

- In-process to confirm that standards are maintained

- Pre-shipping to ensure that the product arrives to the customer exactly as expected and is packaged

correctly to prevent any damage in transit.

   We can help operating split shipments, meeting the factory minimum quantity but ship them in 2 or 3 shipments with required gaps among. This allows you to move stock through your business without taking up space and capital.

We will arrange the subsequent shipments from our factory to your warehouse.

We can consolidate your small orders from multiple factories, delivering all at the same time to you or your customers,using the most cost-effective route available. At the time of order placement, we will offer details to you about the volume of each component part and what size container will be used.

  We can offer the complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.

   Delivery can be offered.

    - Utilizing your own freight-forwarder

    - FOB to a port in China

    - CIF to a port near you

   Whether you have your own freight-forwarder or you would like to organize shipment; whether you require delivery FOB in China or CIF to a port near you, we are glad to quote and supply whichever way you choose. Please feel free to discuss all options with us.

1.Client is first.We are trying to bring maximum profit to our clients and we only share small.

2.Credibility is the most important.

3.Quality control is our life.

4.Great sense of responsibility.

We will be responsible for not only our products, our clients, our suppliers, also the society.