(1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7 CAS NO.126456-43-7

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(1S,2R)-(-)-cis-1-Amino-2-indanol Basic information

Reaction

Product Name:	(1S,2R)-(-)-cis-1-Amino-2-indanol
Synonyms:	5R)-LGH447 dihydrochloride;(1S,2R)-(-)-cis-1-Amino-2-hydroxyindane 126456-43-7 (1S,2R)-(-)-cis-1-Amino-2-indanol;(1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7;(1S,2R)-(-)-cis-1-Amino-2-indanol,99%;(1S,2R)-(−;(1S, 2R)-Trans-1-AMino-2-indanol;(1S,2R)-(-)-1-Amino-2,3-dihydro-1H-inden-2-ol, (1S,2R)-(-)-1-Aminoindan-2-ol;(1S,2R)-1-Amino-2,3-dihydro-inden-2-ol
CAS:	126456-43-7
MF:	C9H11NO
MW:	149.19
EINECS:
Product Categories:	Chiral Nitrogen;organic alcohol;Amino Alcohols (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;CHIRAL CHEMICALS;chiral;API intermediates;CHIRAL COMPOUNDS;Indinavir Sulfate
Mol File:	126456-43-7.mol

(1S,2R)-(-)-cis-1-Amino-2-indanol Chemical Properties

Melting point	118-121 °C(lit.)
alpha	-62 º (c=0.5, CHCl3)
Boiling point	270.27°C (rough estimate)
density	1.0753 (rough estimate)
refractive index	1.5760 (estimate)
RTECS	NK7525500
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	14.79±0.40(Predicted)
form	Powder
color	White to light beige
optical activity	[α]20/D 61°, c = 0.5 in chloroform
Water Solubility	slightly soluble
Sensitive	Air Sensitive
BRN	4292559
InChIKey	LOPKSXMQWBYUOI-BDAKNGLRSA-N
CAS DataBase Reference	126456-43-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22
Safety Statements	26-36-36/37/39
RIDADR	3259
WGK Germany	3
F	10-23
TSCA	No
HazardClass	8
HS Code	29052900

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

(1S,2R)-(-)-cis-1-Amino-2-indanol Usage And Synthesis

Reaction	Ligand component used in the chromium-catalyzed highly selective asymmetric ene reactions between aryl aldehydes and alkoxy- and silyloxyalkenes. Ligand component for the chromium-catalyzed highly enantioselective o inverse-demand hetero-Diels-Alder reactions of α,β-unsaturated aldehydes. Ligand component for the magnesium-catalyzed conjugate addition reaction of 1,3-dicarbonyl compounds to nitroalkenes. Component for stereoselective asymmetric 6π-azaelectrocyclization through the reaction between the (E)-3- carbonyl-2,4,6-trienal compounds and the (-)-7-alkyl-cis-1-amino-2-indanol derivatives. Ligand component for palladium-catalzyed asymmetric azaelectrocyclization for the preparation of 2,4- disubstituted chiral 1,2,5,6-tetrahydropyridines. Component for organocatalytic conjugate addition of formaldehyde N,N-dialkylhydrazones to β,γ -Unsaturated α-keto esters. N-Sulfinyl urea organocatalyst component for enantioselective aza-henry reaction. Component for organocatalytic enantioselective additions of indoles to nitroalkenes.
Chemical Properties	white to light yellow crystal powder
Uses	1S,2R)-(-)-cis-1-Amino-2-indanol may be used to prepare: (-)-1,2,5,6-Tetrahydropyridine by reacting with methyl (E,E)-4-oxo-2-[(2,6,6-trimethylcyclohex-1-enyl)vinyl}but-2-enoate. Oxazaborolidine catalysts, which can catalyze the asymmetric reduction of aromatic ketones with high enantioselectivity. (RS,1S,2R)-(-)-2,4,6-Trimethylbenzenesulfinic acid 1-(2,4,6-trimethylbenzenesulfonylamino)indan-2-yl ester.
Uses	(1S,2R)-(-)-cis-1-Amino-2-indanol is used as a reagent in the synthesis of heterocyclic compounds as integrase inhibiting antiviral agents. It is also a key intermediate of the HIV protease inhibitor, Indinavir (I525000).
General Description	(1S,2R)-(-)-cis-1-Amino-2-indanol is a main constituent of indinavir, a potent HIV (human immunodeficiency virus) protease inhibitor.

(1S,2R)-(-)-cis-1-Amino-2-indanol Preparation Products And Raw materials

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