A nonsteroidal aromatase inhibitor,Antineoplastic drugs LetrozoleCAS:112809-51-5 CAS NO.112809-51-5

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99%(1-9)Kilogram1026/Kilogram1USD99%(10-20)Kilogram1012/Kilogram10USD

Product Details

Keywords

Letrozole
112809-51-5
Potassium tert-butanolate-->3-Amino-5-mercapto-1,2,4-triazole-->4-Cyanobenzyl bromide

Quick Details

ProName: A nonsteroidal aromatase inhibitor,Ant...
CasNo: 112809-51-5
Molecular Formula: C17H11N5
Appearance: White powder
Application: A nonsteroidal aromatase inhibitor str...
DeliveryTime: Shipped in 15 days after payment
PackAge: according to customers' requirements
Port: China main port
ProductionCapacity: 10000 Metric Ton/Month
Purity: 98%min
Storage: -20°C Freezer
Transportation: Air, sea, land transport
LimitNum: 1 Kilogram
Residue on Ignition: 0.1% max
Heavy Metal: 10ppm max
Valid Period: 2 years

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Details

Introduction:

1.CAS NO: 112809-51-5

2.letrozole Content: 99%

3.Molecular Formula: C17H11N5

4. Molecular Weight: 285.31

5. Appearance white or off-white powder

6. Melting point 181-183 ° C

7. Letrozole is an oral non-steroidal inhibitor for the treatment of hormonally-responsive breast cancer after surgery. letrozole prevents the aromatase from producing estrogens by competitive, reversible binding to the heme of its cytochrome p450 unit, the action is specific,and letrozol does not reduce production of mineralo-or corticosteroids.

Letrozole is a new generation aromatase inhibitor, is a synthetic derivative of benzyl triazole, letrozole by inhibiting aromatase, estrogen levels drop, thereby eliminating the stimulating effect of estrogen on tumor growth. Chemotherapy and radiotherapy for breast cancer.

Function:

Letrozole is a new generation of highly selective aromatase inhibitors for synthetic benzyl triazole derivatives, by inhibiting aromatase, estrogen levels drop, thereby eliminating the stimulating effect of estrogen on tumor growth. In vivo activity than the first-generation aromatase inhibitor aminoglutethimide 150-250 times stronger. Due to its high selectivity, without affecting glucocorticoid mineralocorticoid and thyroid function, high doses of a corticosteroid like substances secreted without inhibition, and therefore it has a high therapeutic index. The pre-clinical studies have shown that letrozole for the whole body system and there is no potential target organ toxicity, no mutagenic and carcinogenic effects, and less side effects, well tolerated, and other aromatase inhibitors and anti- estrogen drugs compared to stronger anti-tumor effect. Suitable for patients with early breast cancer treatment as well as anti-estrogen therapy after treatment of advanced breast cancer in postmenopausal invalid.

Main Application:

1. Treatment of postmenopausal women with advanced breast cancer (estrogen receptor, progesterone receptor positive or unknown receptor status), used for anti-estrogen therapy after the failure of second-line treatment;

2. For locally advanced or spread after the first-line treatment of postmenopausal breast cancer (foreign data);

3. For the received standard adjuvant tamoxifen therapy in postmenopausal breast cancer after five years of adjuvant therapy in patients with extension (foreign data);

4. Postoperative adjuvant therapy for hormone-positive early breast cancer patients.

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