Lappaconitine is an active ingredient isolated from the roots of Aconitum sinomontanum Nakai. Its hydrobromide was proven to be a medicine with extensive applications by the Chinese scientists. And it possesses the effects of local anaesthesia, defervescence, antiphlogosis and detumescence.
Function:
1.Analgesic effect
Hypermorphine hydrobromide can affect the central nervous system voltage-dependent sodium channel to inhibit axonal injury caused by ectopic discharge, play a role in blocking nerve conduction; by inhibiting the presynaptic membrane of norepinephrine and Serotonin re-uptake, so that synaptic clearance increased, thereby inhibiting the release of fiber and somatostatin release and play a strong and lasting analgesic effect; analgesic effects in addition to these mechanisms, but also with the inhibition of brain Water around the gray matter and cortical calcium influx and so on.
2. anti-inflammatory swelling effect
The body damage can induce inflammatory cells to produce a large number of chemokines, triggering the immune response, immune factors, immune factors can stimulate, induce and regulate the inflammatory response, but also activate the neuroendocrine system to produce stress hormones, the body in a stress state. Hyperbarergenic hydrobromide can reduce the inflammatory response of the local tissue of the wound, reduce the formation and absorption of inflammatory mediators, block the stimulation of the neuroendocrine system and mobilize the immune system of the starting factors, indicating that the high eruption It has the effect of inhibiting postoperative stress response and acute and chronic inflammation, and it provides a theoretical basis for its clinical treatment of rheumatism, rheumatoid arthritis caused by swelling and pain.
3. The role of the heart
Hydrogenated hydrobromide is a natural compound with antiarrhythmic effects that can inhibit the depolarization of the heart directly or indirectly by regulating the expression of the voltage dependent sodium / potassium channel and the associated protein gene on the channel; The excitability of the cardiac conduction system exerts its antiarrhythmic effect. Hypermorphine hydrobromide can reduce myocardial contractility by increasing the myocardial excitability by arranging potential-dependent sodium channels, leading to bradycardia or cardiac arrest, in order to exert its antiarrhythmic effects.
4. Other effects
Recent studies have found that, in addition to analgesic, antiarrhythmic and anti-inflammatory swelling has a good role, but also has antiepileptic, anti-tumor, anti-bacterial, anti-oxidation and immune regulation and so on. Hypermorphine hydrobromide can control epilepsy activity by inhibiting hippocampal neuronal activity.
Application:
1. Lappaconitine hydrobromide has the heart stimulating effect.
2. Lappaconitine hydrobromide used for Anti-cancer and anti inflammatory.
3. Lappaconitine hydrobromide can be used to local anesthesia, refrigeration, anti-inflammation and detumescence.
4. Lappaconitine hydrobromide used in sweating profusely with body temperature dropping; muscle spasm in cholera.
5. Lappaconitine hydrobromide used in the treatment of rheumatism, intermittent fevers and acute inflammatory infections.
Specification: