China (Mainland)
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Camptotheca Acuminata Extract camptothecin CAS:7689-03-4 CAS NO.7689-03-4
- FOB Price: USD: 86.00-100.00 /Gram Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
99%(1-9)Gram99%(10-20)Gram
- Product Details
Keywords
- 7689-03-4
- (+)-Camptothecin
- Irinotecan
Quick Details
- ProName: Camptotheca Acuminata Extract camptoth...
- CasNo: 7689-03-4
- Molecular Formula: C20H16N2O4
- Appearance: light yellow crystal powde
- Application: Antitumor agent;Topoisomerase I inhibi...
- DeliveryTime: ship goods within 3-5 days after paid
- PackAge: [Packaging]20mg, 50mg,100mg,1g,10g,10...
- Port: china main port
- ProductionCapacity: 10000 Kilogram/Month
- Purity: 99%
- Storage: 2-8°C
- Transportation: Air, sea, land transport
- LimitNum: 1 Gram
- Plant of Origin: Solvent Extraction
- Testing Method: HPLC
- Product Ecification: 99%
- Heavy Metal: <0.002%
- Voluntary Standards: GK
Superiority
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present, our customers have spread all over the world, we have rich Transportation experience, we aim to serve customers, to help customers, solve problems for customers. Look forward to working with you!
Details
Introduction:
Camptothecin is a plant secondary metabolite used as an anti-cancer drug that damages DNA, leading to the destruction of the cell. It comes from Camptotheca acuminata, a deciduous tree found in southern China. A close analogue, 9-methoxycamptothecin, is also present in the same source.
Mechanism of Action:
Camptothecin affects the activity of the enzyme topoisomerase I, whose normal action is to cleave, unwind, and religate DNA. When camptothecin binds to topoisomerase I, it will be able to cleave but not to religate DNA. Thereby, camptothecin causes single strand breaks in DNA.
Function：
1.Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I,
by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately
causes tumor cell death.
2.In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication,
it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes.
If the chromosomes cannot be unwound, transcription of DNA message cannot occur and
the protein cannot be synthesized, it ultimately causes cell death.
3.Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility. 4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.
Application:
1.Treatment Gastrointestinal cancer and leukemia,
2.Plant growth regulator activity and kill insects.
3.Treatment of gastric cancer, liver cancer, head and neck cancer and leukemia,, with fewer side effects than camptothecine.
Specification：
All Key Manufacturers and Suppliers of Baoji Guokang have routine inspections to ensure they are in compliance with the standards set in place during the original Supplier Assessment Inspection.
Production Inspection Process:
Our Group service includes regular and thorough inspections throughout the manufacturing process, eliminating the need to employ additional quality control inspectors.
- Raw material before any production begins
- Pre-production samples to ensure specifications are being met
- In-process to confirm that standards are maintained
- Pre-shipping to ensure that the product arrives to the customer exactly as expected and is packaged correctly to prevent any damage in transit.
We can help operating split shipments, meeting the factory minimum quantity but ship them in 2 or 3 shipments with required gaps among. This allows you to move stock through your business without taking up space and capital.
We will arrange the subsequent shipments from our factory to your warehouse.
We can consolidate your small orders from multiple factories, delivering all at the same time to you or your customers,using the most cost-effective route available. At the time of order placement, we will offer details to you about the volume of each component part and what size container will be used.
We can offer the complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.
Delivery can be offered.
- Utilizing your own freight-forwarder
- FOB to a port in China
- CIF to a port near you
Whether you have your own freight-forwarder or you would like to organize shipment; whether you require delivery FOB in China or CIF to a port near you, we are glad to quote and supply whichever way you choose. Please feel free to discuss all options with us.
1.Client is first.We are trying to bring maximum profit to our clients and we only share small.
2.Credibility is the most important.
3.Quality control is our life.
4.Great sense of responsibility.
We will be responsible for not only our products, our clients, our suppliers, also the society.
