7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE 380844-49-5 CAS NO.380844-49-5

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7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Basic information

Product Name:	7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE
Synonyms:	7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE;7-(3-Chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile;7-(3-chloropropoxy)-4-(2,4-dichloro-5-methoxyanilino)-6-methoxyquinoline-3-carbonitrile;Bosutinib intermediate;Bosutinib Impurity 24;Bosutinib Impurity 31;3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-;7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE ISO 9001：2015 REACH
CAS:	380844-49-5
MF:	C21H18Cl3N3O3
MW:	466.74
EINECS:
Product Categories:
Mol File:	Mol File

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Chemical Properties

Melting point	183-186℃
Boiling point	585.6±50.0 °C(Predicted)
density	1.43
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform (Slightly, Sonicated), DMSO (Slightly)
pka	3.71±0.50(Predicted)
form	Solid
color	Pale Yellow to Light Yellow

Safety Information

MSDS Information

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Usage And Synthesis

Uses	1-Chloro-1-desmethylpiperazinyl-bosutinib is a useful intermediate in the green preparation of the anti-tumor agent Bosutinib (B676095). It is a COVID19-related research product.

7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Preparation Products And Raw materials

The pharmacological efficacy

Expand coronary arteries and increase coronary blood flow

 

Effects on the heart and peripheral blood vessels

 

Inhibition of platelet aggregation

 

Broad-spectrum antibacterial and anti-inflammatory effects

Protocatechuic aldehyde is one of the main active ingredients of the treatment of nephritis.

 

Antioxidant: 7 phenolic acids isolated from the water-soluble part of Salvia miltiorrhiza: salvianolic acid A, salvianolic acid B, protocatechuic aldehyde, protocatechuic acid, danshensu, caffeic acid and rosmarinic acid, It has a strong protective effect on the peroxidation damage of biofilm. In vitro, it inhibits the adhesion of leukocytes and vascular endothelial cells induced by TNF-a, and inhibits the expression of ICAM-1 and VCAM-1 in vascular endothelial cell adhesion molecules.

 

Calcium antagonism

Both Danshensu and protocatechuic aldehyde have the effect of reducing the cytoplasmic Ca2+ concentration in adult erythrocytes, and they are dose-dependent. The two drugs are combined and the effects are similar. It is similar to Danshen injection, which is the antagonist of Danshen injection calcium. The main active ingredient of the action.

Repair damaged venous valve to treat varicose veins

 

Protective effect on brain tissue ischemia and reperfusion injury.

Enhance the ability to resist hypoxia and improve renal function.

 

   All Key Manufacturers and Suppliers of Baoji Guokang have routine inspections to ensure they are in compliance with the standards set in place during the original Supplier Assessment Inspection.

 

Production Inspection Process:

Our Group service includes regular and thorough inspections throughout the manufacturing process, eliminating the need to employ additional quality control inspectors.

- Raw material before any production begins

- Pre-production samples to ensure specifications are being met

- In-process to confirm that standards are maintained

- Pre-shipping to ensure that the product arrives to the customer exactly as expected and is packaged

correctly to prevent any damage in transit.

   We can help operating split shipments, meeting the factory minimum quantity but ship them in 2 or 3 shipments with required gaps among. This allows you to move stock through your business without taking up space and capital.

We will arrange the subsequent shipments from our factory to your warehouse.

We can consolidate your small orders from multiple factories, delivering all at the same time to you or your customers,using the most cost-effective route available. At the time of order placement, we will offer details to you about the volume of each component part and what size container will be used.

  We can offer the complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.

   Delivery can be offered.

    - Utilizing your own freight-forwarder

    - FOB to a port in China

    - CIF to a port near you

   Whether you have your own freight-forwarder or you would like to organize shipment; whether you require delivery FOB in China or CIF to a port near you, we are glad to quote and supply whichever way you choose. Please feel free to discuss all options with us.

1.Client is first.We are trying to bring maximum profit to our clients and we only share small.

2.Credibility is the most important.

3.Quality control is our life.

4.Great sense of responsibility.

We will be responsible for not only our products, our clients, our suppliers, also the society.