Antianemic drugs Calcium folinateCAS:1492-18-8 CAS NO.1492-18-8

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Product Details

Keywords

Calcium folinate
1492-18-8
Antianemic drugs

Quick Details

ProName: Antianemic drugs Calcium folinateCAS:1...
CasNo: 1492-18-8
Molecular Formula: C20H21CaN7O7
Appearance: Light yellow to yellow solid
Application: antianemic, antidote to folic acid ant...
DeliveryTime: Shipped in 15 days after payment
PackAge: according to customers' requirements
Port: China main port
ProductionCapacity: 10000 Metric Ton/Month
Purity: 99%
Storage: 2-8°C
Transportation: Air, sea, land transport
LimitNum: 500 Gram
Related Substances: <3.0%
Residue on Ignition: <1.0%
Heavy Metal: <0.002%
Valid Period: 2 years

Superiority

Calcium folinate is an antidote of the folic acid antagonists. At room temperature, it appears as yellowish white to yellow crystalline or amorphous powder, being odorless. It is easily soluble in water, but almost insoluble in ethanol or ether, and easily soluble in sodium hydroxide solution. Calcium folinate is a formylated derivative of folic acid, acting similarly to folic acid, being the activated form of folic acid in the body. After entering into the human body, it is converted to tetrahydrofolic acid under the action of tetrahydrofolate reductase, being effective in fighting against methotrexate-induced toxicity. Calcium folinate has effect of "rescuing" the in vivo toxicity of the excess amount of folic acid antagonists, being conducive to thymidine, DNA, RNA and protein synthesis, being able to stimulate white blood cell growth and maturation. This product can limit the damage degree of methotrexate to normal cells by competing with each other. It is also able to reverse the reaction of methotrexate on bone marrow and gastrointestinal mucosa, but has no effect on the existing methotrexate neurotoxicity.

Details

Introduction:

Chemical Name:Calcium folinate

Synonyms:Folinic acid calcium salt;

N-(4-(((2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid calcium salt

Molecular Formula:C20H21N7O7.Ca

Molecular Weight:511.51

CAS No.:1492-18-8

EINECS:216-082-8

Characters:Off-white to yellowish crystalline or amorphous powders, no smell.

Standard:CP, EP, USP

Solubility:The product dissolves in water and can not dissolve in ethanol or ether, and it easily dissolves in 0.1mol/L sodium hydroxide solution.

Packing:As per customers demand

Application:Pharmaceutical intermediates

Function:

Calcium folinate (CF) itself has no anti-tumor effect and is mainly used for high-dose rescue and concurrent use with fluorouracil to enhance the latter's therapeutic effect.

Another kind of therapy is the combination of calcium folinate and fluorouracil used to improve the efficacy of the latter one, commonly known as the CF-FU combination therapy. The basic principle is that: during the process of DNA synthesis, deoxyuridine (dUMP) needs to be catalyzed by adenylate synthase (TMPS) to accept the formyl group transferred from tetrahydrofolate (THF) to generate deoxyadenylic acid (dTMP).

Application:

1.It is mainly used as the antidote of folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.).

2.It can be used for the prevention of severe toxicity after excessive or large doses administration of methotrexate.

3.The megaloblastic anemia caused by folic acid deficiency.

4.In combination with fluorouracil, it is used for the treatment of advanced colon cancer and rectal cancer.

It is used for the rescue of the toxicity reaction caused by excessive amount of aminopterin and methotrexate as well as being used for the treatment of giant red blood cell anemia.

The efficacy of folate can offset the effects of folic acid antagonists. The folic acid antagonists rely on binding to folic acid dehydrogenase (DHFR), thereby preventing folate from converting to folic acid. Medically, after the chemotherapy of methotrexate, the calcium folinate can be used to reduce methotrexate toxicity. Calcium folinate can be used to enhances the cytotoxic effect of 5-fluorouracil in anticancer fields.

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Production Inspection Process:

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- Raw material before any production begins

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