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Polyene antifungal antibiotics amphotericin bCAS:1397-89-3 CAS NO.1397-89-3
- FOB Price: USD: 865.00-890.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
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- Available Specifications:
99%(1-9)Kilogram99%(10-20)Kilogram
- Product Details
Keywords
- Amphotericin B
- 1397-89-3
- antifungal drugs
Quick Details
- ProName: Polyene antifungal antibiotics amphote...
- CasNo: 1397-89-3
- Molecular Formula: C47H73NO17
- Appearance: yellow powder
- Application: Polypeptide antibiotic active against ...
- DeliveryTime: Shipped in 15 days after payment
- PackAge: according to customers' requirements
- Port: China main port
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Refrigerator
- Transportation: Air, sea, land transport
- LimitNum: 1 Kilogram
- Related Substances: 5’CMP 0.3%
- Residue on Ignition: 0.01%
- Heavy Metal: 0.002%
- Valid Period: 2 years
Superiority
Amphotericin B is a kind of polyene antifungal antibiotics isolated from the culture medium of the Streptomyces (Streptomycesnodosus) .
Details
Introduction:
Product Name :Amphotericin B
Molecular Formula :C47H73NO17
Molecular Weight :924.079
CAS Registry Number :1397-89-3
EINECS :215-742-2
Density :1.34g/cm3
Melting point :>170°C
Boiling point:1140.365°C at 760 mmHg
Refractive index :1.614
Flash point :643.47°C
Water solubility :<0.1 g/100 mL at 21°C
Vapour Pressur :0mmHg at 25°C
Amphotericin B (Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec) is a polyene antifungal drug, often used intravenously for systemic fungal infections. It was originally extracted from Streptomyces nodosus, a filamentousbacterium, in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the Orinoco River region of Venezuela. Its name originates from the chemical's amphoteric properties. Two amphotericins, amphotericin A and amphotericin B are known, but only B is used clinically, because it is significantly more activein vivo. Amphotericin A is almost identical to amphotericin B (having a double C=C bond between the 27th and 28th carbons), but has little antifungal activity.
Currently, the drug is available as plain amphotericin B, as a cholesteryl sulfate complex (ABCD), as a lipid complex (ABLC), and as a liposomal formulation (LAmB). The latter formulations have been developed to improve tolerability for the patient, but may show considerably different pharmacokinetic characteristics compared to plain amphotericin B.
Function:
Amphotericin B is the first-choice drug for treating deep fungus infection with a broad antifungal spectrum. It has inhibitory effect on cryptococcus, coccidioidomyces immitis, candida albicans, and blastomyces with exhibiting bactericidal effect at high concentration, and therefore is a kind of drugs being effective in treating deep fungus infection. Major clinical indications are as follows:
1. It can be used for the treatment of cryptococcosis, North American blastomycosis, disseminated candidiasis, coccidioidomycosis, and histoplasmosis.
2. It can be used for the treatment of mucormycosis caused by the rhizopus genera, absidia, endomycopsis and the basidiobulus sp.
3. It can be used for the treatment of sporotrichum disease caused by schenker sporotrichosis.
4. It can be used for the treatment of aspergillosis caused by the Aspergillus fumigatus.
5. External preparation is suitable for treating chromomycosis, fungal infections infection after burning, respiratory tract candida, Aspergillus or cryptococcus infection, and fungal corneal ulcer.
Specification:
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